AID mistargeting to enhancers
نویسندگان
چکیده
منابع مشابه
Enhancers, enhancers - from their discovery to today's universe of transcription enhancers.
Transcriptional enhancers are short (200-1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene. Originally discovered in simian virus 40 (SV40), a small DNA virus, transcription enhancers were soon also found in immunoglobulin genes and other cellular genes as key determinants of cell-type-specific gene expression. Enhancers can exert...
متن کاملConvergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability
Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-dependent cytidine deamination of single-stranded DNA targets. Though largely specific for immunoglobulin genes, AID also acts on a limited set of off-targets, generating oncogenic translocations ...
متن کاملB Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity
The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously damages oncogenes, leading to chromosomal translocations and tumorigenesis. Why nonimmunoglobulin loci are susceptible to AID activity is unknown. Here, we study AID-mediated lesions in the context of nuclear architecture and the B cell regulome. We show that AID targets are not randomly distributed across the g...
متن کاملLedPred: Learning from DNA to Predict enhancers
2 Description 2 2.1 Data . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.2 Learning from CRM-contained information to predict new regulatory features . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2.2.1 Building the training set . . . . . . . . . . . . . . . . . . . 2 2.2.2 Optimization of support vector machine model . . . . . . 3 2.2.3 Definition of the opti...
متن کاملGenetic enhancers.
A genetic enhancer is a mutation in one gene that intensifies the phenotype caused by a mutation in another gene. The phenotype of the double mutant is much stronger than the summation of the single mutant phenotypes. The isolation of enhancers can lead to the identification of interacting genes, including genes that act redundantly with respect to each other. Examples in Caenorhabditis elegans...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Genetics
سال: 2015
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.3209